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Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice
Authors:Papadopoulos Theofilos  Korte Martin  Eulenburg Volker  Kubota Hisahiko  Retiounskaia Marina  Harvey Robert J  Harvey Kirsten  O'Sullivan Gregory A  Laube Bodo  Hülsmann Swen  Geiger Jörg R P  Betz Heinrich
Affiliation:Department of Neurochemistry, Max-Planck-Institute for Brain Research, Frankfurt, Germany.
Abstract:Collybistin (Cb) is a brain-specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding protein gephyrin found at glycinergic and GABAergic synapses. Here we show that Cb-deficient mice display a region-specific loss of postsynaptic gephyrin and GABA(A) receptor clusters in the hippocampus and the basolateral amygdala. Cb deficiency is accompanied by significant changes in hippocampal synaptic plasticity, due to reduced dendritic GABAergic inhibition. Long-term potentiation is enhanced, and long-term depression reduced, in Cb-deficient hippocampal slices. Consistent with the anatomical and electrophysiological findings, the animals show increased levels of anxiety and impaired spatial learning. Together, our data indicate that Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization.
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