Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol |
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| Authors: | Richter Rowena K Mickus Daniel E Rychnovsky Scott D Molinski Tadeusz F |
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| Affiliation: | Department of Chemistry, University of California, Davis, CA 95616, USA. |
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| Abstract: | The addition of exogenous ent-cholesterol suppressed the antifungal activity of the amphotericin B when added to cultures of Candida albicans, but to a lesser extent than natural cholesterol. There were no detectable differences between added 2a or 2b on the antifungal activities of jaspamide or bengazole A, two unrelated antifungal natural products. |
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