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Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells |
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| Authors: | Aki Iwai Dimitra Bourboulia Mehdi Mollapour Sandra Jensen-Taubman Sunmin Lee Alison C. Donnelly Soichiro Yoshida Naoto Miyajima Shinji Tsutsumi Armine K. Smith David Sun Xiaolin Wu Brian S. Blagg Jane B. Trepel William G. Stetler-Stevenson Len Neckers |
| Affiliation: | 1.Urologic Oncology Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA;2.Radiation Oncology Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA;3.Medical Oncology Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA;4.Department of Medicinal Chemistry; University of Kansas; Lawrence, KS USA;5.Laboratory of Molecular Technology; SAIC-Frederick; National Cancer Institute at Frederick; Frederick, MD USA |
| Abstract: | |
| Keywords: | Wee1 apoptosis cancer heat shock protein 90 molecular targeted anticancer drugs |