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Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study
Authors:Huai Wu Yuan  Chun Xue Wang  Ning Zhang  Ying Bai  Yu Zhi Shi  Yong Zhou  Yi Long Wang  Tong Zhang  Juan Zhou  Xin Yu  Xin Yu Sun  Zhao Rui Liu  Xing Quan Zhao  Yong Jun Wang
Affiliation:1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; 2. Department of Neurology, Beijing Daxing District Hospital, Capital Medical University, Beijing, China.; 3. Institute of Mental Health, Peking University, Beijing, China.; University of Münster, Germany,
Abstract:

Background

Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year.

Methods and Results

This was a multi-centered prospective cohort study. A total of 2306 patients with acute stroke were enrolled in our study. PSD was diagnosed according to the criteria set by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). The outcomes of recurrent stroke were followed up via face-to-face or phone interview. A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrent stroke at 1 year. Multivariate logistic regression analysis showed a 49% increase of OR of recurrent stroke at 1 year in patients with PSD, compared to patients without PSD following a stroke (OR = 1.49, 95%CI: 1.03–2.15). There was no significant correlation between anti-depressant drugs and the risk of recurrent stroke at 1 year following a stroke (OR = 1.96, 95%: CI 0.95–4.04).

Conclusions

Based on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosed with PSD at 2 weeks following a stroke. PSD is associated with a higher risk of recurrent stroke at 1 year. Our study did not find benefit of anti-depressant drugs in reducing such risk.
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