Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 |
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| Authors: | Powers Jay P Li Shyun Jaen Juan C Liu Jinqian Walker Nigel P C Wang Zhulun Wesche Holger |
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| Affiliation: | Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. jppowers@amgen.com |
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| Abstract: | High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4. |
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