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| 缺血预处理对缺血/再灌注离体心脏的保护作用 | |
| 作者姓名： | Cao X Gu XQ Yang SJ Zhang HQ |
| 作者单位： | 1. 吉林大学药学院药理教研室,吉林,长春,130021 2. 吉林大学第三临床医院,吉林,长春,130021 3. 吉林大学物理学院,吉林,长春,130021 |
| 摘 要： | 目的：探讨连续多次短暂缺血预处理对缺血/再灌注损伤心肌的保护作用及机制。方法：采用大鼠离体心脏Lan-gendorff灌流模型,观察缺血预处理对心肌缺血/再灌注后不同时间点冠脉流出液中AST、CPK、UDH及冠脉流量,心肌组织中SOD、LPO以及再灌注性心律失常的影响。结果：缺血预处理可以减少缺血/再灌注损伤的心肌冠脉流出液中AST、CPK、LDH的含量,提高心肌SOD活性,降低LPO水平,并且抑制再灌注性心律失常的发生,提高再灌注期间的冠脉流量。结论：缺血预处理对心肌缺血/再灌注损伤具有一定保护作用。 |
| 关 键 词： | 缺血预处理 缺血／再灌注损伤 心肌 SOD活性 冠脉流出液 再灌注性心律失常 冠脉流量 |
| 文章编号： | 1000-6834(2003)02-0114-03 |
| 修稿时间： | 2002年5月15日 |
The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats |
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| Cao X,Gu XQ,Yang SJ,Zhang HQ.The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats[J].Chinese Journal of Applied Physiology,2003,19(2):114-116. | |
| Authors: | Cao Xia Gu Xin-quan Yang Shi-jie Zhang Hui-qing |
| Institution: | Department of Phanmaology, Jilin University, Jilin Changchun 130021, China. |
| Abstract: | Aim: To investigate the protective effects and mechanism of IPC on myocardial ischemia/reperfusion injury. Methods: Effects of IPC on arrhythmia and coronary blood flow and the release of AST, CPK, LDH, SOD and LPO at different time after ischemia/reperfusion injury in rat Langendorff hearts were studied. Results: IPC decreased the release of AST, CPK and LDH and increased myocardial SOD activity and decreased LPO level. IPC also inhibited ischemia/reperfusion arrhythmias and increased coronary blood flow. Conclusion: The results showed that IPC had well protective effects on myocardial ischemia/reperfusion injury. |
| Keywords: | IPC isolated heart myocardial ischemia/reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |