Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro |
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| Authors: | Oku Hirosuke Wongtangtintharn Sawitree Iwasaki Hironori Toda Takayoshi |
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| Institution: | Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus, Nishihara, Okinawa, Japan. okuhiros@comb.u-ryukyu.ac.jp |
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| Abstract: | This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of 14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS. |
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