Big G,little G: G proteins and actin cytoskeletal reorganization |
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Authors: | Luttrell Louis M |
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Institution: | The Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. |
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Abstract: | It has been known for some time that stimulation of heterotrimeric G protein-coupled receptors can cause cytoskeletal reorganization. A recent report in Developmental Cell demonstrates that the activation of a tyrosine kinase, C-terminal Src kinase, by heterotrimeric G protein subunits provides the trigger for Rho-dependent actin stress fiber formation. |
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