| 椒葛软胶囊溶出度的研究 |
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| 引用本文： | 宋喆,肖会敏,李阳,王剑波,王四旺. 椒葛软胶囊溶出度的研究[J]. 现代生物医学进展, 2010, 10(5) |
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| 作者姓名： | 宋喆 肖会敏 李阳 王剑波 王四旺 |
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| 作者单位： | 第四军医大学药学系药物研究所,陕西,西安,710032 |
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| 基金项目： | 陕西省“13115”工程技术研究中心资助课题(S2010ZDGC105) |
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| 摘 要： | 目的:建立椒葛软胶囊体外溶出度及测定方法。方法:以0.1M盐酸胃蛋白酶溶液900ml为介质,转速为200r/min;采用HPLC法测定椒葛软胶囊的体外溶出度。结果:在60分钟椒葛软胶囊的溶出度均大于标示量(70%)。结论:该法测定椒葛软胶囊的溶出度,方法稳定、可行。
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| 关 键 词： | 溶出度 葛根素 椒葛软胶囊 盐酸:胃蛋白酶 高效液相色谱法 |
Dissolution rate of Jiaoge Soft Capsule |
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| SONG Zhe,XIAO Hui-min,LI Yang,WANG Jian-bo,WANG Si-wang. Dissolution rate of Jiaoge Soft Capsule[J]. Progress in Modern Biomedicine, 2010, 10(5) |
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| Authors: | SONG Zhe XIAO Hui-min LI Yang WANG Jian-bo WANG Si-wang |
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| Abstract: | Objective:To establish a method for determination dissolution rate of Jiaoge soft capsule in vitro.Method:The solution containing 0.1M chlorhydric acid and 1% pepsase was used as dissolution medium and the dissolution rates were determined by HPLC.Result: The dissolution rates of Jiaoge soft capsule were significant higher than labeled amoun(t70%)at 60min.Conclusion: This method was steady and suitable for the test of the dissolution rate of Jiaoge sof t capsules. |
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| Keywords: | dissolution rate puerarin Jiaoge soft capsule chlorhydric acid pepsin HPLC |
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