Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study |
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| Authors: | Mandana Nikpour Murray B Urowitz Dominique Ibanez Paula J Harvey Dafna D Gladman |
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| Institution: | (1) University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada;(2) The University of Melbourne Departments of Medicine and Rheumatology, St. Vincent’s Hospital, 41 Victoria Parade, Fitzroy, Melbourne, Victoria, 3065, Australia;(3) Division of Cardiology, Women’s College Hospital, 790 Bay Street, Suite 708, Toronto, ON, M5G 1N8, Canada |
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| Abstract: | Introduction Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a
small proportion of the dramatically increased risk of atherosclerotic coronary artery disease (CAD) in systemic lupus erythematosus
(SLE). However, in these studies, exposure to risk factors was measured only at baseline. In this study, our objective was
to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP),
and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE. |
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