A Model for Calcium Permeation into Small Intestine |
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Authors: | Barbara Dolinska Agnieszka Mikulska Artur Caban Aneta Ostrozka-Cieslik Florian Ryszka |
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Institution: | (1) Pharmaceutical Research and Production Plant, Biochefa, Kasztanowa 3, 41-205 Sosnowiec, Poland;(2) Department of Applied Pharmacy, Medical University of Silesia, Sosnowiec, Poland;(3) Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland |
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Abstract: | An in vitro model was used to simulate the intestinal permeation of calcium ions depending on the type of salt (carbonate,
fumarate, citrate, or gluconate), its concentration (1.0, 2.5, 5.0, or 10 mM/l), and pH (1.3, 4.2, 6.2, or 7.5). To simulate
the conditions for calcium permeation in a patient in a fasting state, the solutions were placed in contact with segments
of small intestine of pig: stomach, duodenum, jejunum, and ileum. The percent permeation, its rate, and half-time were measured
in each case. In all cases, the maximum permeation was seen at 1 mM concentration, depending on pH: 100% for carbonate at
pH 1.3; 82% for fumarate, pH 6.2; 79.5% for citrate at pH 4.2, and 81% for gluconate at pH 7.4. The maximum rate of permeation
(% h−1) was also observed at 1 mM: 2.16 for carbonate at pH 1.3, 0.29 for fumarate at pH 6.2, 0.26 for citrate at pH 4.2, and 0.28
for gluconate at pH 7.4. The shortest half-time permeation (t
1/2, h) for 1 mM solutions depended also on pH (in parentheses): carbonate 0.3 (1.3), fumarate 2.4 (6.2), citrate 2.6 (4.2),
and gluconate 2.5 (7.4). The results suggest that calcium carbonate and citrate can be recommended to patients with normal
gastric acidity and hyperacidity while fumarate and gluconate to patients with hypoacidity. |
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