Hip1 and Hippi participate in a novel cell death-signaling pathway |
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| Authors: | Wanker Erich E |
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| Institution: | Neuroproteomics Section, Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, D-13125 Buch, Berlin, Germany. |
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| Abstract: | Neuronal apoptosis is a cardinal feature of late-onset neurodegenerative disorders such as Alzheimer's and Huntington's disease. Biochemical and cell biological studies point to a role for Hip1 and Hippi in caspase-8 activation and the initiation of apoptosis during the pathogenesis of Huntington's disease. |
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