Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

Authors:	Li Guiying Zhou Hao Jiang Yu Keim Holger Topiol Sidney W Poda Suresh B Ren Yong Chandrasena Gamini Doller Darío

Institution:	^a Department of Chemical & Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Rd., Paramus, NJ 07652, USA ^b Department of Biological Research, Lundbeck Research USA, 215 College Rd., Paramus, NJ 07652, USA

Abstract:	Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT₁ and MT₂ receptors are reported. Compounds 11f and 18b (MT₁/MT₂ agonist) have human microsomal intrinsic clearance comparable to ramelteon.

Keywords:	WHNBFHNVGXNLCB-UHFFFAOYSA-N IQYNIMPSBOGDGR-ZDUSSCGKSA-N
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