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Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety |
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| Authors: | Hutchinson Douglas K Flentge Charles A Donner Pamela L Wagner Rolf Maring Clarence J Kati Warren M Liu Yaya Masse Sherie V Middleton Tim Mo Hongmei Montgomery Debra Jiang Wen W Koev Gennadiy Beno David W A Stewart Kent D Stoll Vincent S Molla Akhteruzzaman Kempf Dale J |
| Affiliation: | Department of Antiviral Research, Department of Drug Metabolism and Pharmacokinetics, Department of Structural Biology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA |
| Abstract: | A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays. |
| Keywords: | Hepatitis C NS5B polymerase inhibitors Benzothiadiazine Bioisosteres |
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