Substituted imidazole derivatives as novel cardiovascular agents |
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Authors: | Malhotra Vineet Pathak Seema R Nath Rajendra Mukherjee Devashish Shanker K |
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Institution: | a Applied Chemistry, ASET, Amity University, Haryana, India b Department of Pharmacology & Therapeutics, CSJMMU, Lucknows, India c NIC college of Engineering, Faizabad Rd, Lucknow, India |
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Abstract: | A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive and bradycardiac responses. Compounds 3b, 3c, 3f and 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50 >1000 mg/kg with maximum in 2e and 4c (>1200 mg/kg). |
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Keywords: | Arylidine hydrazides Substituted oxadiazole Imidazole Hypotensive activity Carotid occlusion NE response |
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