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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1 |
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| Authors: | Gopalsamy Ariamala Kincaid Scott L Ellingboe John W Groeling Thomas M Antrilli Thomas M Krishnamurthy Girija Aulabaugh Ann Friedrichs Gregory S Crandall David L |
| Affiliation: | Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA. gopalsa@wyeth.com |
| Abstract: | A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described. |
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