The effect of the plasma needle on tumoral cell lines apoptosis |
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Authors: | Calugaru Ana Cremer Lidia Herold Aurora Lupu Andreea Szegli G Lungu C Lungu Ana Georgescu N |
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Institution: | N.I.R.D.M.I. "Cantacuzino", Immunomodulation Department, Bucharest, Romania. |
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Abstract: | In this paper, we present the effect of the plasma needle on tumor cell surface. The plasma is generated at the tip of a metal needle by using a radio-frequency generator of 13.56 MHz, 100's V amplitude. In our study we investigated the interaction of non-thermal plasma (plasma needle) with living monolayer tumour cells in culture medium. We applied short needle to sample distance (1 mm) at temperature of 25 degrees C, 30 degrees C and 37 degrees C, respectively. Our data sugest that the plasma needle reduces the viability and induces apoptosis of tumour cells. These activities may be very useful in dermatology, where a part of the tissue must be removed with high-precision, without damage to the adjacent cells and without inflammatory reaction. |
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