Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis |
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Authors: | Egidija Sakiniene and L Vincent Collins |
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Institution: | (1) Department of Rheumatology, University of G?teborg, Sweden |
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Abstract: | Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of Staphylococcus aureus arthritis. |
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