Enhanced prolactin inhibition following chronic treatment with haloperidol and morphine |
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| Authors: | H Lal W Brown R Drawbaugh M Hynes G Brown |
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| Affiliation: | 1. Dept. of Pharmacology & Toxicology University of Rhode Island Kingston, R. I. 02881, USA;2. Dept. of Psychiatry, Brown University Medical School and VA Hospital, Providence, R. I. 02908, USA;3. Clarke Institute of Psychiatry, Toronto, Canada |
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| Abstract: | Withdrawal from chronic haloperidol or morphine treatment resulted in lower circulating levels of serum prolactin in male rats. A low dose of apomorphine (0.32 mg/kg), which had no effect on serum prolactin in untreated rats, diminished serum prolactin in the treated rats. A lower dose of apomorphine (0.08 mg/kg) also ineffective in control rats, elevated serum prolactin in the treated rats. |
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