Ethanol-induced changes in methionine metabolism in rat liver |
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Authors: | J D Finkelstein J P Cello W E Kyle |
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Affiliation: | Veterans Administration Hospital and George Washington University School of Medicine, Washington, D.C. 20422 USA |
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Abstract: | The administration of alcohol to rats fed a protein-restricted diet results in significant changes in the hepatic content of four enzymes of methionine metabolism. The levels of s-adenosylmethionine synthetase, cystathionine synthase, and betaine-homocysteine methyltransferase increase while the level of methyltetrahydrofolate-homocysteine methyltransferase decreases. These changes represent a reversal of the normal adaptive response to protein-restriction. The resultant impairment in methionine conservation could explain the alcohol-induced increase in the dietary lipotrope requirement. |
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