Bile acid-oligodeoxynucleotide conjugates: synthesis and liver excretion in rats |
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Authors: | Starke D Lischka K Pagels P Uhlmann E Kramer W Wess G Petzinger E |
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Institution: | Institute of Pharmacology and Toxicology, Justus-Liebig-University, Giessen, Germany. |
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Abstract: | The synthesis of bile acid oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid-oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides. |
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