Adenylate kinase 2, a mitochondrial enzyme |
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| Authors: | Bruns Gail A P Regina Violet M |
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| Institution: | (1) Division of Clinical Genetics, The Children's Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | The subcellular compartmentalization of the isozymes of ATP: AMP phosphotransferase (adenylate kinase) was analyzed in HeLa cells, RAG cells, and RAG-human hybrids that express human AK-2. In HeLa cells and in the hybrids, human AK-2 was present in a mitochondrial fraction prepared from cell extracts and in mitochondria purified by density gradient centrifugation. Human AK-1 was, as expected, distributed in the soluble cytoplasmic fraction of the cells. The rodent isozymes which are homologous to human AK-1 and AK-2 have been determined.This work was supported by NIH Grants HD 04807-07 and HD 06285-04. |
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| Keywords: | adenylate kinase 2 isozymes mitochondria HeLa cells mouse RAG cells adenylate kinase 1 |
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