X-ray crystallographic and high-resolution NMR spectroscopy characterization of 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hex-2-enopyranosyl sulfamide期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

X-ray crystallographic and high-resolution NMR spectroscopy characterization of 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hex-2-enopyranosyl sulfamide

Authors:	Colinas Pedro A Bravo Rodolfo D Echeverría Gustavo A

Affiliation:	^a LADECOR, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900 La Plata, Argentina ^b LANADI e IFLP (CCT-La Plata), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CC 67, 1900 La Plata, Argentina

Abstract:	Single crystal X-ray diffraction and high-resolution ¹H and ¹³C NMR spectral data for 4,6-di-O-acetyl-2,3-dideoxy-α-d-erythro-hex-2-enopyranosyl sulfamide, a selective inhibitor of carbonic anhydrase isozyme IX, are reported. The ⁰H₅ was found to be the preferred form for this glycosyl sulfamide, both in the crystal lattice and in solution.

Keywords:	N-Glycosyl sulfamide X-ray diffraction Single crystal ⁰H₅ conformation
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