Use of a recycle-type SEC method as a powerful tool for purification of thiosialoside derivatives |
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Authors: | Sakamoto Jun-Ichi Takita Chiharu Koyama Tetsuo Hatano Ken Terunuma Daiyo Matsuoka Koji |
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Institution: | Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan |
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Abstract: | An efficient separation between fully acetylated thiosialoside methyl esters and fully acetylated Neu5Ac2en methyl esters was accomplished by means of a size-exclusion chromatography (SEC) method. Purity determinations and structural elucidation of the isolated compounds were performed by a combination of elemental analyses and spectroscopic analyses, including IR, 1H, and 13C NMR, and mass spectroscopic analyses. |
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Keywords: | Thioglycosides Sialic acid SEC purification Sialooligosaccharides Glycals |
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