Antibacterial Activities of Novel Diselenide-bridged bis(Porphyrin)s on Staphylococcus aureus Investigated by Microcalorimetry |
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| Authors: | Xiang-jiao Xu Zhi Xue Qi Xiao An Xin Hou Yi Liu |
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| Affiliation: | (1) State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People’s Republic of China;(2) College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, Hubei, 430081, People’s Republic of China |
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| Abstract: | The actions of two novel diselenide-bridged bis(porphyrin)s (1 and 2) on Staphylococcus aureus growth was investigated by microcalorimetry at 37.00°C, compared with that of Na2SeO3. Differences in their capacities to inhibit the growth metabolism of S. aureus were observed. By analyzing the power–time curves, crucial parameters such as the rate constant of bacterial growth (k), inhibitory rate (I), and generation time (t G) were determined. The growth rate constant (k) of S. aureus (in the log phase) in the presence of the drugs decreased with increasing concentrations of the drugs regularly. The relationship of k and c is nearly linear for diselenide-bridged bis(porphyrin) 2. The sequence of the antibacterial activities of these selenium compounds tested was 2 > 1 > Na2SeO3. |
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| Keywords: | Diselenide-bridged bis(porphyrin)s Staphylococcus aureus Antibacterial activities Microcalorimetry Thermokinetics |
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