Y-190, a DNA probe for the sensitive detection of Y-derived marker chromosomes and mosaicism |
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| Authors: | Ulrich Müller Timothy A Donlon Susan M Kunkel Marc Lalande Samuel A Latt |
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| Institution: | (1) Division of Genetics and Mental Retardation Center, Children's Hospital, 300 Longwood Avenue, 02115 Boston, MA, USA;(2) Department of Pediatrics, Harvard Medical School, Boston, Maas., USA;(3) Department of Genetics, Harvard Medical School, Boston, Maas., USA;(4) Howard Hughes Medical Institute, Boston, Maas., USA;(5) Present address: Department of Pathology, Stanford University, 94305 Stanford, CA, USA;(6) Present address: Biotechnology Institute, Montreal, Canada |
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| Abstract: | Summary A DNA probe (Y-190) is described that specifically hybridizes with repeated DNA sequences in the short arm of the human Y chromosome. The suitability of Y-190 to detect Y-derived DNA is shown in two patients with a 45,X/46,X+marker earyotype and in a third patient previously described as having a 45,X karyotype. |
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