Enzymatic cleavage of human neurophysin into 2 sub-domains containing 3 and 4 disulfides |
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| Authors: | J Chauvet G Michel M T Chauvet R Acher |
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| Affiliation: | Laboratoire de Chimie biologique, Université Pierre-et-Marie-Curie, Paris. |
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| Abstract: | Native human MSEL-neurophysin has been subjected to trypsin hydrolysis. Because of a change of the bond Lys59-Pro60 found in other mammalian neurophysins into Lys59-Ala60 in human protein, a peculiar cleavage has occurred in the latter, leading to a split of the molecule into two halves. The N-terminal sub-domain contains 4 disulfide bridges whereas the C-terminal one possesses 3 disulfide bridges. |
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