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Rapid Particle Size Measurement Using 3D Surface Imaging
Authors:Ira Soppela  Sari Airaksinen  Juha Hatara  Heikki Räikkönen  Osmo Antikainen  Jouko Yliruusi  Niklas Sandler
Affiliation:.Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5E), 00014 Helsinki, Finland ;.Hatara Consulting, Helsinki, Finland ;.Pharmaceutical Sciences Laboratory, Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku, Finland
Abstract:The present study introduces a new three-dimensional (3D) surface image analysis technique in which white light illumination from different incident angles is used to create 3D surfaces with a photometric approach. The three-dimensional features of the surface images created are then used in the characterization of particle size distributions of granules. This surface image analysis method is compared to sieve analysis and a particle sizing method based on spatial filtering technique with nearly 30 granule batches. The aim is also to evaluate the technique in flowability screening of granular materials. Overall, the new 3D imaging approach allows a rapid analysis of large amounts of sample and gives valuable visual information on the granule surfaces in terms of surface roughness and particle shape.
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