Regional Expression of Key Cell Cycle Proteins in Brain from Subjects with Amnestic Mild Cognitive Impairment |
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Authors: | Rukhsana Sultana D Allan Butterfield |
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Institution: | (1) Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055, USA;(2) Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA;(3) Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506, USA |
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Abstract: | Mild cognitive impairment (MCI) is regarded as a transition stage between the cognitive changes of normal aging and the more
serious problems caused by Alzheimer’s disease (AD). Previous studies had demonstrated increased expression of cell cycle
proteins in AD brain. In the present study, we have analyzed the expression of the cell cycle proteins, CDK2, CDK5 and cyclin
G1 in hippocampus and inferior parietal lobule (IPL) in subjects with amnestic mild cognitive impairment and control using
Western blot analysis. The expression of CDK2, CDK5 and cyclin G1 were found to be significantly increased in MCI hippocampus
as well as in IPL compared to control brain. These results suggest that some cells may have re-entered the cell cycle. However,
the expression of CDK2 and CDK5 is greater in MCI hippocampus compared to those of MCI IPL, and hippocampus is a region that
is severely affected by AD pathology. Since these proteins are involved directly or indirectly in microtubule destabilization
and hyperphosphorylation of tau, and also in APP processing we hypothesize that cell cycle disturbance may be important contributor
in the pathogenesis of AD.
Special issue dedicated to Dr. John P. Blass. |
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Keywords: | Amnestic mild cognitive impairment Amnestic Hippocampus Inferior parietal lobule CDK2 CDK5 Cyclin G1 |
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