Effect of actinomycin D and cycloheximide on lipoproteins in blood serum and liver cytosol of rats under oxidative stress

The influence of protein synthesis inhibitors on rat lipoprotein content and composition under oxidative stress caused by cobalt chloride injection has been investigated in the present work. It has been concluded that apoprotein synthesis is very important process influencing on adaptive reactions under free-radical oxidation activation conditions. Co-administration of cobalt chloride and actinomycin D or cycloheximide (the inhibitors of the protein synthesis) has realy prevented hyperlipoproteinemia in many cases but hasn't influenced on lipoprotein oxidation. Pre-beta- and beta-lipoproteins were discussed to have mRNA pool in hepatocytes.