A three dimensional model of the digestion of peptidoglycan by lysozyme |
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Authors: | H Formanek |
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Institution: | (1) Botanisches Institut der UniversitÄt München, Menzinger Stra\e 67, D-8000 München 19, Federal Republic of Germany |
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Abstract: | The digestion of single peptidoglycan chains of the recently proposed conformation (Formanek et al., 1974) can be described with the same enzymatic mechanism as proposed by Phillips for a hexasaccharide consisting of alternating N-acetylglucosamine, N-acetylmuramic acid residues (Phillips, 1966). It is shown by model building, that in a peptidoglycan lysozyme complex the peptide chains do not exhibit any sterical hindrance.The digestion of the peptidoglycan sacculus by lysozyme may occur at lattice defects of its paracrystalline structure. A slit of about 30 å lenght and 10–15 å width between peptidoglycan micells may be sufficient for the attachment of lysozyme. |
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Keywords: | Peptidoglycan Lysozyme Model Building |
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