Arginases in parasitic diseases |
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Authors: | Vincendeau Philippe Gobert Alain P Daulouède Sylvie Moynet Daniel Mossalayi M Djavad |
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Institution: | Equipe d'accueil Immunologie moléculaire et Parasitologie, Université de Bordeaux II, 146 rue Léo Saignat, Bordeaux 33076, France. philippe.vincendeau@parasito.u-bordeaux2.fr |
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Abstract: | Parasites have elaborated a variety of strategies for invading hosts and escaping immune responses. This article proposes that a common mechanism whereby different parasites escape nitric oxide (NO) toxicity is the activation of arginase. This leads to a depletion of l-arginine (substrate of NO synthase, resulting in lower levels of cytotoxic NO) and increased production of polyamines (necessary for parasite growth and differentiation). |
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