Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: protective effects of SkQ1, lithium ions and insulin |
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| Authors: | Plotnikov E Y Vasileva A K Arkhangelskaya A A Pevzner I B Skulachev V P Zorov D B |
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| Institution: | A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia; Center of Mitoengineering, Moscow State University, Moscow 119991, Russia. |
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| Abstract: | Mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenyl-phosphonium (SkQ1) as well as insulin and the inhibitor of glycogen-synthase kinase, Li(+) are shown to (i) protect renal tubular cells from an apoptotic death and (ii) diminish mitochondrial fission (the thread-grain transition) induced by ischemia/reoxygenation. However, SkQ1 and LiCl protected the mitochondrial reticulum of skin fibroblasts from ultraviolet-induced fission but were ineffective in preventing a further cell death. This means that mitochondrial fission is not essential for apoptotic cascade progression. |
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| Keywords: | SkQ1 10-(6-plastoquinonyl)decyltriphenyl-phosphonium ROS reactive oxygen species GSK glycogen-synthase kinase TMRE tetramethylrhodamine ethyl ester UV ultraviolet |
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