Synthesis of a natural chalcone and its prenyl analogs--evaluation of tumor cell growth-inhibitory activities, and effects on cell cycle and apoptosis |
| |
Authors: | Neves Marta P Lima Raquel T Choosang Kanthima Pakkong Panee de São José Nascimento Maria Vasconcelos M Helena Pinto Madalena Silva Artur M S Cidade Honorina |
| |
Institution: | Centro de Química Medicinal da Universidade do Porto-CEQUIMED-UP, Rua Aníbal Cunha 164, PT-4050-047 Porto. |
| |
Abstract: | Six prenyl (=3-methylbut-2-en-1-yl) chalcones (=1,3-diphenylprop-2-en-1-ones), 2-7, and one natural non-prenylated chalcone, 1, have been synthesized and evaluated for their in vitro growth-inhibitory activity against three human tumor cell lines. A pronounced dose-dependent growth-inhibitory effect was observed for all prenylated derivatives, except for 7. The chalcone possessing one prenyloxy group at C(2'), i.e., 2, was the most active derivative against the three human tumor cell lines (5.9
|
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|