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| Roles of insulin-like growth factor Ⅱ in regulating female reproductive physiology | |
| 摘 要： | The number of growth factors involved in female fertility has been extensively studied, but reluctance to add essential growth factors in culture media has limited progress in optimizing embryonic growth and implantation outcomes, a situation that has ultimately led to reduced pregnancy outcomes. Insulin-like growth factor Ⅱ(IGF-Ⅱ) is the most intricately regulated of all known reproduction-related growth factors characterized to date, and is perhaps the predominant growth factor in human ovarian follicles. This review aims to concisely summarize what is known about the role of IGF-Ⅱ in follicular development, oocyte maturation, embryonic development, implantation success, placentation, fetal growth, and in reducing placental cell apoptosis, as well as present strategies that use growth factors in culture systems to improve the developmental potential of oocytes and embryos in different species. Synthesizing the present knowledge about the physiological roles of IGF-Ⅱ in follicular development, oocyte maturation, and early embryonic development should, on the one hand, deepen our overall understanding of the potential beneficial effects of growth factors in female reproduction and on the other hand support development(optimization) of improved outcomes for assisted reproductive technologies. |
Roles of insulin-like growth factor II in regulating female reproductive physiology |
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| Muhammad,Tahir,Li,Mengjing,Wang,Jianfeng,Huang,Tao,Zhao,Shigang,Zhao,Han,Liu,Hongbin,Chen,Zi-Jiang. Roles of insulin-like growth factor II in regulating female reproductive physiology[J]. Science China Life sciences, 2020, 63(6): 849-865. DOI: 10.1007/s11427-019-1646-y | |
| Authors: | Muhammad Tahir Li Mengjing Wang Jianfeng Huang Tao Zhao Shigang Zhao Han Liu Hongbin Chen Zi-Jiang |
| Affiliation: | 1.Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China ;2.National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, China ;3.Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, 250012, China ;4.Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, 250012, China ;5.Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200000, China ;6.Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200000, China ; |
| Abstract: | The number of growth factors involved in female fertility has been extensively studied, but reluctance to add essential growth factors in culture media has limited progress in optimizing embryonic growth and implantation outcomes, a situation that has ultimately led to reduced pregnancy outcomes. Insulin-like growth factor II (IGF-II) is the most intricately regulated of all known reproduction-related growth factors characterized to date, and is perhaps the predominant growth factor in human ovarian follicles. This review aims to concisely summarize what is known about the role of IGF-II in follicular development, oocyte maturation, embryonic development, implantation success, placentation, fetal growth, and in reducing placental cell apoptosis, as well as present strategies that use growth factors in culture systems to improve the developmental potential of oocytes and embryos in different species. Synthesizing the present knowledge about the physiological roles of IGF-II in follicular development, oocyte maturation, and early embryonic development should, on the one hand, deepen our overall understanding of the potential beneficial effects of growth factors in female reproduction and on the other hand support development (optimization) of improved outcomes for assisted reproductive technologies. |
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