Iron trafficking as an antimicrobial target |
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Authors: | Rosanne E Frederick Jeffery A Mayfield Jennifer L DuBois |
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Institution: | (1) Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA |
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Abstract: | Iron is essential for the survival of most organisms. Microbial iron acquisition depends on multiple, sometimes complex steps,
many of which are not shared by higher eukaryotes. Depriving pathogenic microbes of iron is therefore a potential antimicrobial
strategy. The following minireview briefly describes general elements in microbial iron uptake pathways and summarizes some
of the current work aiming at their medicinal inhibition. |
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Keywords: | Iron Antibiotic Siderophore |
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