The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity |
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| Authors: | Jade E Hollis-Moffatt Peter J Gow Andrew A Harrison John Highton Peter BB Jones Lisa K Stamp Nicola Dalbeth Tony R Merriman |
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| Affiliation: | (1) Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin, 9012, New Zealand;(2) Department of Rheumatology, Middlemore Hospital, 100 Hospital Road, Auckland, 2025, New Zealand;(3) Department of Medicine, University of Otago, 23A Mein Street, Wellington, 6242, New Zealand;(4) Department of Medicine, University of Otago, 201 Great King Street, Dunedin, 9016, New Zealand;(5) Department of Medicine, University of Auckland, 2 Park Road, Auckland, 1023, New Zealand;(6) Department of Medicine, University of Otago, 2 Riccarton Avenue, Christchurch, 8140, New Zealand |
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| Abstract: | Introduction The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout. There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples. |
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