| 检验点激酶1的研究进展 |
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| 引用本文： | 李昌军,刘凯于,杨东叶,余泽华,彭建新,陈文,谢飞.检验点激酶1的研究进展[J].细胞生物学杂志,2006,28(2):149-152. |
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| 作者姓名： | 李昌军 刘凯于 杨东叶 余泽华 彭建新 陈文 谢飞 |
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| 作者单位： | 华中师范大学昆虫学研究所 武汉430079 |
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| 摘 要： | 检验点激酶1(checkpointkinase1,Chk1)为一种进化保守的蛋白激酶,是细胞检验点的转导因子。当电离辐射、紫外线等引起细胞DNA损伤或者DNA复制叉停滞时Chk1活化,诱导细胞产生细胞周期阻滞、DNA修复或细胞凋亡等特征。现对Chk1的结构、功能以及病毒通过Chk1调控宿主细胞周期等方面进行简述。
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| 关 键 词： | 检验点激酶1 ATR DNA损伤检验点 促成熟因子 DNA损伤信号/修复蛋白 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005-11-21 |
Progress in Checkpoint Kinase 1 |
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| Chang-Jun Li,Kai-Yu Liu,Dong-Ye Yang,Ze-Hua Yu,Jian-Xin Peng,Wen Chen,Fei Xie.Progress in Checkpoint Kinase 1[J].Chinese Journal of Cell Biology,2006,28(2):149-152. |
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| Authors: | Chang-Jun Li Kai-Yu Liu Dong-Ye Yang Ze-Hua Yu Jian-Xin Peng Wen Chen Fei Xie |
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| Institution: | Institute of Entomology, Central China Normal University, Wuhan 430079, China |
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| Abstract: | Checkpoint kinase 1 (Chk1), an evolutionarily conserved protein kinase, is an effector of cellDNA damage checkpoint. When DNA was damaged or DNA replication fork halted by ionization radiation or ultra-violet radiation, Chk1 was activated, which induced cell cycle arrest, DNA repair or cell apoptosis. In this review,we described the structure and function of Chk1 and discussed how the virus regulate the cell cycle of host cell bymanipulating Chk1. |
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| Keywords: | Chk1 ATR DNA damage checkpoint MPF DNA damage signaling/repair protein |
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