Ever-changing cell interactions during the life span of the corpus luteum: Relevance to luteal regression |
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| Institution: | 1. Laboratory of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA;2. Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel;1. University of Wisconsin-Madison, Madison, Wisconsin, USA;2. University of São Paulo, Piracicaba, Brazil;3. Uludag University, Bursa, Turkey;1. Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, USA;2. Department of Obstetrics & Gynecology, College of Medicine, Oregon Health & Sciences University, Portland, OR, USA;1. School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil;2. Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;3. Institute of Health Sciences, Paulista University, São Paulo, Brazil;4. Faculty of Veterinary Medicine, University of Western São Paulo, Presidente Prudente, Brazil;1. Institute for Maternal and Child Research (IDIMI), Chile;2. Department of Obstetrics and Gynecology, Faculty of Medicine, San Borja-Arriaran Clinical Hospital, University of Chile, Santiago, Chile;3. Department of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States;1. Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, PR China;2. Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, 400016, PR China;3. College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China |
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| Abstract: | The corpus luteum (CL) undergoes dramatic morphological and functional changes throughout its lifespan. It initially develops from cells that remain in the follicle following ovulation. Eventually the mature CL is composed of multiple, distinctive cell types including steroidogenic cells (small and large luteal cells) and other cell types (endothelial cells, pericytes, fibroblasts, and immune cells). Robust angiogenesis accompanies CL formation, establishing an elaborate blood vessel network at mid cycle. In the absence of embryonic signals, the CL will regress in a process triggered by prostaglandin F2α (PG). Luteal demise in the responsive gland is characterized by cessation of steroid production, angio-regression, and apoptotic cell death, brought about by leukocyte infiltration, inflammatory responses, and diminished angiogenic support. However, the young immature CL is resistant or refractory to the luteolytic actions of PG. Evidence based on functional genomics and other studies highlight the roles played by endothelial, immune, and steroidogenic luteal cells and their interactions in the PG-responsive vs. PG-refractory CL. |
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| Keywords: | Luteolysis Prostaglandin F2α Angiogenesis Endothelial cells Immune cells |
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