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Morphological evaluation of sperm from infertile men selected by magnetic activated cell sorting (MACS) |
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| Affiliation: | 1. Bourn Hall Clinic, Bourn, Cambridge CB23 2TN;2. Anatomy School and Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK;1. Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany;2. Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany |
| Abstract: | Electron microscopy analysis performed in five infertile human subjects after sperm selection by swim-up followed by magnetic activated cell sorting (MACS) demonstrated a decrease in the number of spermatozoa with characteristics compatible with cell death. However, no significant differences were found when the swim-up/MACS semen fraction was compared with swim-up fraction alone. |
| Keywords: | Annexin V Apoptotic sperm DNA damage Magnetic activated cell sorting Electron microscopy |
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