Long-term adverse effects of cyclophosphamide on follicular growth and angiogenesis in mouse ovaries |
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| Affiliation: | 1. College of Chemistry & Environment, Guangdong Ocean University, Zhanjiang 524088, China;2. College of Agriculture, Guangdong Ocean University, Zhanjiang 524088, China |
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| Abstract: | The adverse effects of the anti-cancer agent cyclophosphamide (CTX) on follicular growth and ovarian angiogenesis were investigated in mice. CTX treatment irreversibly induced a loss of follicles through apoptosis and decreased microvascularization of the corpora lutea and follicles in a dose-dependent manner. Our findings demonstrated that CTX adversely affected the ovaries indicating the need to support an awareness of fertility preservation before chemotherapy is initiated. |
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| Keywords: | Cyclophosphamide Follicular growth Corpus luteum Angiogenesis |
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