Evaluation of a Nanoemulsion-Based Formulation for Respiratory Delivery of Budesonide by Nebulizers |
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| Authors: | Amir Amani Peter York Henry Chrystyn Brian J Clark |
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| Institution: | (1) Institute of Pharmaceutical Innovation, School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK;(2) Department of Medical Nanotechnology, School of Advanced Medical Nanotechnology, Tehran University of Medical Sciences, Tehran, 1417614411, Iran;(3) School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK |
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| Abstract: | The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The in vitro characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved in vitro performance for the nanoemulsion-based preparations. |
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