Preparation of biodegradable polylactide microparticles via a biocompatible procedure |
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Authors: | Levato Riccardo Mateos-Timoneda Miguel A Planell Josep A |
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Affiliation: | Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain. |
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Abstract: | PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 μm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques. |
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