1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors |
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| Authors: | Takeuchi K Bastian J A Gifford-Moore D S Harper R W Miller S C Mullaney J T Sall D J Smith G F Zhang M Fisher M J |
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| Institution: | Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. ktak@lilly.com |
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| Abstract: | A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors. An indole with basic diamine moieties (12a) was the most potent thrombin inhibitor in the series with Kass= 197 x 10(6) L/mol. |
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