Transesterification of alkylphosphate esters by phospolipase D |
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Authors: | I Aurich P Dürrschmidt F Hirche R Ulbrich-Hofmann |
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Institution: | (1) Department of Biochemistry/Biotechnology, Martin-Luther University, Halle-Wittenberg, D-6099 Halle, Federal Republic of Germany |
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Abstract: | Phospholipase D from cabbage or Streptomyces chromofuscus catalyses the transesterification of alkylphosphate esters, which are potent antitumor agents. The exchange of choline in octadecylphosphosphocholine by N-(2-hydroxy-ethyl)-N-methylpiperidine with phospholipase D from cabbage is kinetically controlled and amounts to maximum 60% in buffer, 43% in buffer/n-hexane, and 82% in buffer/n-hexane/1-octanol. |
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