Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity |
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| Authors: | Stella Peña Laura Scarone Eduardo Manta Lindsay Stewart Vanessa Yardley Simon Croft Gloria Serra |
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| Institution: | Cátedra de Química Farmacéutica, DQO, Facultad de Química, UDELAR, Montevideo CP 11800, Uruguay. |
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| Abstract: | The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain). |
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