LN-5 antibody against human macrophages cross-reacts with routinely processed human sebaceous glands |
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Authors: | Grzegorz J Lis Jan A Litwin Alicja Furga?-Borzych Gra?yna Pyka-Fo?ciak |
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Institution: | Department of Histology Jagiellonian University Medical College, Krakow, Poland. mmlis@cyf-kr.edu.pl |
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Abstract: | LN-5 monoclonal antibody against human macrophages was found to selectively stain human sebaceous glands in formalin-fixed, paraffin-embedded skin samples. Undifferentiated sebocyte progenitors were negative, and only sebocytes from the onset of their differentiation revealed positive cytoplasmic immunofluorescence. Since there are very few selective and easy-to-use markers of sebaceous glands, LN-5 antibody can offer a simple and relatively specific way to detect human sebocytes from the onset of their differentiation in routinely processed material, both freshly prepared and archival. |
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