Structure-Function Relationship of Three Triple-Helical Nucleic Acids |
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| Authors: | Andrea Giacometti |
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| Affiliation: | Department of Environmental Science Facoltà di Scienze MM.FF.NN. , University “Ca' Foscari” of Venice , Calle Larga S. Marta, 2137, I-30123 , Venezia , Italy |
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| Abstract: | Abstract The nucleic acid triplexes poly d(T)·poly d(A)·poly d(T), poly (U)·poly (A)·poly (U), and poly (I)·poly (A)·poly (I) display a sort of continuity between each other. However, their morphologies present their own individuality which, considering those of their parent duplexes, are quite unexpected. This comparison helps to understand triplex structure-function relationship. While helical parameters are functions of the sugar pucker, low values of WC and Hoogsteen base-pair propellers is commonplace for triplexes and the Hoogsteen base-pair geometry monitors the effects of the interstrand phosphates charge-charge repulsion. Synopsis The nucleic acid triplexes poly d(T)·poly d(A)·poly d(T), poly(U)·poly(A)·poly(U), and poly (I)·poly (A)·poly (I) present distinct morphologies. Considering those of their parent duplexes, they are also quite unexpected. |
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| Keywords: | Chromium(III) complexes Specific viscosity Zeta potential Tryptic Oglycanase digestion |
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