Nucleosomal Positioning and Genetic Divergence Study Based on DNA Flexibility Map |
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| Authors: | Sudip Kundu Dhananjay Bhattacharya Ashoke Ranjan Thakur Rabi Majumdar |
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| Institution: | 1. Department of Biophysics, Molecular Biology &2. Genetics , University College of Science , 92 APC Road, Calcutta , 700009 , India;3. Biophysics Division , Saha Institute of Nuclear Physics , 37 Belgachia Road, Calcutta , 700037 , India |
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| Abstract: | Abstract Based on worm like chain model, DNA structural parameters—tilt, roll and rise, derived from crystallographic database have been used to determine the flexibility of DNA that regulates the nucleosomal translational positioning. Theoretically derived data has been compared to the experimental values available in Ioshikhes and Trifonov's database. The methodology has been extended to determine the flexibility of 18S rRNA genome in eukarya, where yeast shows a distinct difference when compared with mammals like human, mouse and rabbit. |
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| Keywords: | Synonymous codon usage Highly expressed genes Lowly expressed genes Mutational bias Translational selection Lactococcus lactis Correspondence analysis |
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