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Loop Fold Structure of Proteins: Resolution of Levinthal's Paradox |
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| Authors: | Igor N Berezovsky Edward N Trifonov |
| Institution: | 1. Department of Structural Biology , The Weizmann Institute of Science , P.O.B. 26, Rehovot , 76100 , Israel;2. Genome Diversity Center , Institute of Evolution University of Haifa , Haifa , 31905 , Israel |
| Abstract: | Abstract According to Levinthal a protein chain of ordinary size would require enormous time to sort its conformational states before the final fold is reached. Experimentally observed time of folding suggests an estimate of the chain length for which the time would be sufficient. This estimate by order of magnitude fits to experimentally observed universal closed loop elements of globular proteins—25–30 residues. |
| Keywords: | Levinthal's paradox protein folding chain conformation closed loops loop fold structure |